Announced at E3 it will be available on the Xbox 360 and PC. Release date is November 17th 2009.

The game will be set in the Southern United States, starting in Savannah, Georgia and ending up in New Orleans, Louisiana. Four new survivors will be introduced, with their backstory provided in a similar way to the original through dialogue in the game. The survivors include Coach, a high-school football coach; Rochelle, a reporter for a local cable company; Ellis, a boy mechanic; and Nick, a gambler and conman.

New melee weapons will be introduced, including a frying pan, an axe, baseball bat, and chainsaw, as well as updates to the existing weapons.